Professor Eggehard Holler has completed his Ph.D. at the age of 27 years from Johann-Wolfgang Goethe University at Frankfurt/Main, Germany and his postdoctoral studies at Cornell University and UC Berkeley. He is Professor at the University of Regensburg and at Cedars-Sinai Medical Center. His scientific merits are in the fields of replication and protein synthesis, platinum anticancer mechanisms, biochemistry of myxomycetes, polymer chemistry and drug delivery. He is the frontier in the design of targeted nano drugs and treatment of tumors in brain and breast. He has contributed over 150 scientific articles and book chapters. Presently he holds position at Nanomedicine Research Center at Neurosurgical Department of CSMC. Research topics on the Enzymology and enzyme mechanisms of aminoacyl-tRNA synthetases, DNA polymerases and associated proteins, Microbiology of Physarum polycephalum, Discovery and function of polymalic acid, Polymalic acid, production and purification, in drug delivery and synthesis of conjugates suitable for drug delivery, Polymalatase recombinant expression & mechanism, Action mechanism of platinum(II) complexes, targeted delivery and action of Estrogen derivatives/collaboration with Dept. of Chemistry and Pharmacy. During 30 years as Professor of Biochemistry at the University of Regensburg, Germany, I supervised 50 theses in PhD & diploma (master), and contributed > 220 research publications (160 peer-reviewed). Over 40 years at the university I was devoted to teaching in Biochemistry, Immunology, Biophysics, and Special Courses. I intensively cooperated through administrative commissions and as the director of the Department of Biophysics and Physical Chemistry. My grant record and extensive professional experience acquired during amply sponsored research projects included topics in Chemistry, Physical Biochemistry, Microbiology and Drug Delivery. Educated as a chemist, I love to gain insight into ligand interactions of complexes ranging from small molecules over polymers to proteins (enzymes) and nucleic acids. When investigating DNA polymerases, I stumbled over polymalic acid (PMLA), at first curious about its biological functions and lately admiring its immense potential to function as a powerful platform to deliver pharmaceutical and other cargo to tissues and cells. The strength of this platform lies in its high number of chemically reactive (carboxylic) groups, its great mobility in solution, its biodegradability and biocompatibility (absence of physiological and genetic toxicity). Thorough numerous quantitative investigations I convincingly demonstrated that reaction with ligands gave all-in-one covalent products of the highly reliable composition. By routine injection, attached cargo can be securely delivered into targeted recipients down to the intracellular level and proved to be extremely useful in tumor imaging and treatment.


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